Resistance by hypermutable Pseudomonas aeruginosa and beta-lactamases production / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
; (12): 54-58, 2009.
Article
em Zh
| WPRIM
| ID: wpr-814252
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE@#To determine the relation between resistance of hypermutable Pseudomonas aeruginosa and beta-lactamases produced.@*METHODS@#The bacteria cultured were identified with API 20NE system. Susceptibilities of the bacteria were detected by disk diffusion method. The hypermutable strains were tested with broth dilution assays. The beta-lactamases produced by these strains were characterized by 3-dimensional test and 2-mercaptopropanoic acid inhibited assays.@*RESULTS@#Altogether 120 strains were analyzed and 45 (37.5%) trains were hypermutable.The resistant rates of hypermutable strains were close to or above 60.0% for imipenem, meropenem, cefoperazone/sulbactam, piperacillin/ tazobactam, ceftazidime, cephfime, aztreonam, amikacin and ciprofloxacin.The 3-dimensional test showed that 18 (40.0%) strains produced extended spectrum beta-lactamases (ESBLs), 25 (55.6%) strains produced AmpC enzymes, and 6 (13.3%) strains produced metallo-beta-lactamases.@*CONCLUSION@#The resistant rates of hypermutablce strains of Pseudomonas aeruginosa to routine antibiotics are high, which is one of the most important reasons for multi-drug resistance that the hypermutable strains produced ESBLs, AmpC enzymes, and metallo-beta-lactamases.
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Pseudomonas aeruginosa
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Doença Cardiopulmonar
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Beta-Lactamases
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Bronquite Crônica
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Farmacorresistência Bacteriana Múltipla
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Genética
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Microbiologia
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Mutação
Limite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
Idioma:
Zh
Revista:
Journal of Central South University(Medical Sciences)
Ano de publicação:
2009
Tipo de documento:
Article