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Expression of plasma thrombospondin-1 in renal interstitial fibrosis / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences) ; (12): 796-802, 2009.
Artigo em Chinês | WPRIM | ID: wpr-814269
ABSTRACT
OBJECTIVE@#To observe the expression of plasma thrombospondin-1(TSP-1) at different time in protein-overload rats and to analyze the relationship between plasma TSP-1 expression and renal interstitial fibrosis.@*METHODS@#Forty-five male Sprague-Dawley rats were randomly divided into a bovine serum albumin (BSA) group and a control group after uninephrectomization. Rats with protein overload nephropathy induced by intraperitoneally injected BSA were used as a model (control group received saline). At the 1st, 5th, and 9th weekend, the level of 24 h proteinuria and renal function was assessed. Pathological changes were observed by electron and fluorescent microscopy. The expression of plasma TSP-1 was detected by Western blot. The relationship between plasma TSP-1 and tubulointerstitial lesions (TIL) score was analyzed.@*RESULTS@#Twenty-four hour proteinuria and blood urea nitrogen (BUN) significantly increased in protein-overload rats compared with those in the control group. While protein-overload rats developed more severe fibrosis in the tubular and interstitium. Glomerulosclerosis index and TIL score were upregulated compared with those in the control group. The expression of TSP-1 increased significantly at the 5th and 9th weekend. The expression of TSP-1 was positively correlated with TIL score (r=0.836, P<0.01).@*CONCLUSION@#Plasma TSP-1 expression is positively correlated with renal interstitial fibrosis in protein-overload rats. Plasma TSP-1 may be used for an important biomarker of renal interstitial fibrosis.
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Patologia / Sangue / Fibrose / Glomerulosclerose Segmentar e Focal / Ratos Sprague-Dawley / Trombospondina 1 / Rim / Metabolismo / Nefrectomia / Nefrite Intersticial Tipo de estudo: Estudo prognóstico Limite: Animais Idioma: Chinês Revista: Journal of Central South University(Medical Sciences) Ano de publicação: 2009 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Patologia / Sangue / Fibrose / Glomerulosclerose Segmentar e Focal / Ratos Sprague-Dawley / Trombospondina 1 / Rim / Metabolismo / Nefrectomia / Nefrite Intersticial Tipo de estudo: Estudo prognóstico Limite: Animais Idioma: Chinês Revista: Journal of Central South University(Medical Sciences) Ano de publicação: 2009 Tipo de documento: Artigo