Change of serum MCP-1 level and CCR2 protein expression in isolated monocytes in patients with acute coronary syndrome / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 318-322, 2009.
Artigo
em Chinês
| WPRIM
| ID: wpr-814329
ABSTRACT
OBJECTIVE@#To investigate the change of serum MCP-1 level and CCR2 expression in isolated monocytes in patients with acute coronary syndrome (ACS) and its possible relationship with ACS pathogenesis.@*METHODS@#Thirty ACS patients and 30 healthy controls were enrolled. Serum MCP-1 levels were determined by ELISA in all subjects. The protein expression of CCR2 in isolated monocytes was assessed by flow cytometry.@*RESULTS@#Serum MCP-1 concentrations in ACS patients were higher than those in healthy controls (P<0.05) and the ratio of CCR2 protein expression in monocytes in ACS patients was higher than that in healthy controls (P<0.01).@*CONCLUSION@#The serum MCP-1 concentrations and protein expression of CCR2 in ACS patients are significantly higher than those in healthy controls, which might be associated with the pathogenesis of ACS.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Sangue
/
Monócitos
/
Estudos de Casos e Controles
/
Quimiocina CCL2
/
Síndrome Coronariana Aguda
/
Receptores CCR2
/
Metabolismo
Tipo de estudo:
Estudo observacional
/
Fatores de risco
Limite:
Adulto
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Journal of Central South University(Medical Sciences)
Ano de publicação:
2009
Tipo de documento:
Artigo
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