Protective effect of calcium channel agonist BayK8644 on lungs against ischemia-reperfusion injury in rabbits / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 1091-1098, 2010.
Artigo
em Chinês
| WPRIM
| ID: wpr-814355
ABSTRACT
OBJECTIVE@#To explore the protective effect of calcium channel agonist BayK8644 preconditioning on the lungs against ischemia-reperfusion injury (I/R) and its mechanism in rabbits.@*METHODS@#Forty rabbits were randomly divided into 4 groups (10 in each group) a sham-operated group (Sham), an I/R group (I/R), an ischemic preconditioning (IP) group (IP), and a BayK8644 preconditioning group(BayK8644).The wet to dry weight (W/D) ratio, superoxide dismutase (SOD) activity, myleoperoxidase (MPO), and malondialdehyde (MDA) contents of the lung tissues were measured after the operation. Morphological and ultrastructural changes of the lung tissue were observed by light and electron microscope. The expression of pulmonary surfactant-associated protein-A (SP-A) was examined with immunohistochemistry.@*RESULTS@#The W/D ratio, MPO and MDA contents of the lung tissue in the BayK8644 group and IP group were significantly lower than those in the I/R group (P0.05).@*CONCLUSION@#Appropriate BayK8644 preconditioning can induce transient Ca²+ influx, and elicit strong protection against the lung ischemia-reperfusion injury, which can simulate the endogenous protective effect of ischemic preconditioning.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Agonistas dos Canais de Cálcio
/
Éster Metílico do Ácido 3-Piridinacarboxílico, 1,4-Di-Hidro-2,6-Dimetil-5-Nitro-4-(2-(Trifluormetil)fenil)
/
Traumatismo por Reperfusão
/
Distribuição Aleatória
/
Precondicionamento Isquêmico
/
Pulmão
/
Métodos
Limite:
Animais
Idioma:
Chinês
Revista:
Journal of Central South University(Medical Sciences)
Ano de publicação:
2010
Tipo de documento:
Artigo
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