Effect of genetic polymorphism on disposition of calcineurin inhibitors in solid organ transplantation / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 1018-1022, 2010.
Artigo
em Chinês
| WPRIM
| ID: wpr-814361
ABSTRACT
Calcineurin inhibitors, tacrolimus and cyclosporine, characterized by a narrow therapeutic index and a high variability in pharmacokinetic behaviors, are 2 basic immunosuppressive drugs widely used in solid organ transplantation. Tailoring of immunosuppressive drug therapy to the specific requirements of individual patients to optimize the efficacy and minimize the toxicity remains one of the biggest challenges for doctors in solid organ transplantation. Pharmacogenetic and pharmacogenomic researches, studying the effect of genetic polymorphism encoding drug metabolizing enzymes, drug transporters and pharmacological target molecules on drug disposition and action, hold promise to produce useful clinical tools for individualizing immunosuppressive therapy.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Polimorfismo Genético
/
Farmacocinética
/
Transplante de Órgãos
/
Tacrolimo
/
Ciclosporina
/
Citocromo P-450 CYP3A
/
Inibidores de Calcineurina
/
Genética
/
Imunossupressores
Limite:
Animais
/
Humanos
Idioma:
Chinês
Revista:
Journal of Central South University(Medical Sciences)
Ano de publicação:
2010
Tipo de documento:
Artigo
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