Change of p-CREB after surgical incisional pain in rat spinal cord / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 833-839, 2010.
Artigo
em Chinês
| WPRIM
| ID: wpr-814387
ABSTRACT
OBJECTIVE@#To explore the role of phosphorylation of cAMP response element binding protein (CREB) in the incision-induced pain hypersensitivity.@*METHODS@#A longitudinal incision was made in one plantar hind paw of isoflurane-anesthetized rats. Spinal cords were removed at various postoperative time after behavior test. Phosphorylation of CREB was determined by immunohistochemistry and double-labeling immunofluorescence. Morphine and gabapentin were intraperitoneally injected before the behavior test and were used to determine the interaction between phosphorylation of CREB and morphine and gabapentin.@*RESULTS@#After the hind-paw incision, phosphorylation of CREB was enhanced in the ipsilateral lumbar spinal cord (P0.05). Gabapentin didn't inhibit the phosphorylation of CREB (P<0.05) but partly inhibited the mechanical allodynia.@*CONCLUSION@#Incision induces the phosphorylation of CREB in the spinal cord, and the increase of p-CREB is mainly in the neurons. Phosphorylation of CREB in the spinal cord contributes to the pain hypersensitivity induced by surgical incision.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Dor Pós-Operatória
/
Fosforilação
/
Medula Espinal
/
Cirurgia Geral
/
Ratos Sprague-Dawley
/
Limiar da Dor
/
Proteína de Ligação ao Elemento de Resposta ao AMP Cíclico
/
Pé
/
Metabolismo
/
Neurônios
Limite:
Animais
Idioma:
Chinês
Revista:
Journal of Central South University(Medical Sciences)
Ano de publicação:
2010
Tipo de documento:
Artigo
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