Advances in molecular genetics research of IgA nephropathy / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 1120-1124, 2011.
Artigo
em Chinês
| WPRIM
| ID: wpr-814471
ABSTRACT
Immunoglobulin A nephropathy (IgAN), which can develop into end-stage renal disease, is the most common primary glomerulonephritis. The pathogenesis of IgAN is not clear. Many studies have confirmed that genetic susceptibility is associated with IgAN, and it belongs to polygenic disease. Some studies have found that IgAN is associated with chromosome 6q22-23, 2q36 by linkage analysis, and several candidate genes have been confirmed to be associated with IgAN, such as angiotensin converting enzyme, Fc fragment of IgA receptor, human leukocyte antigen. In recent years, as the progression of molecular genetics and the Human Genome Project, more attention has been paid to the role of genetic factors in the pathogenesis of IgAN.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Cromossomos Humanos Par 2
/
Cromossomos Humanos Par 6
/
Predisposição Genética para Doença
/
Estudos de Associação Genética
/
Genética
/
Glomerulonefrite
/
Glomerulonefrite por IGA
/
Ligação Genética
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
/
Humanos
Idioma:
Chinês
Revista:
Journal of Central South University(Medical Sciences)
Ano de publicação:
2011
Tipo de documento:
Artigo
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