Correlation studies between urinary retinol binding protein and renal tubular damage / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 1008-1011, 2011.
Artigo
em Chinês
| WPRIM
| ID: wpr-814481
ABSTRACT
OBJECTIVE@#To study correlation between urinary retinol binding protein (RBP) content and renal tubular damage.@*METHODS@#A total of 1 353 healthy people and 186 patients with renal tubular damage diagnosed by renal biopsy were enrolled. The indicators such as endogenous creatinine clearance rate (Ccr), creatinine(Cr), urinary retinol binding protein(RBP), urinary β(2)-microglobulin(β(2)-MG), urinary N-acety1-beta-D-glucosaminidase (NAG), urine specific gravity(SG), urine osmolality of the 2 groups were examined and compared. Score of tubulointerstitial impairing and all indicators were analyzed by Spearman rank correlation analysis, and the sensitivity and specificity of indicators were calculated.@*RESULTS@#Renal tubular damage was positively correlated with urinary RBP, β2-MG, NAG (r=0.863, P<0.001; r=0.777, P<0.001; r=0.374, P=0.002, respectively), while negatively correlated with urine osmolaling, SG (r=-0.519, P<0.001; r=-0.624, P<0.001, respectively). The specificity and sensitivity for renal tubular damage of RBP were 91.03% and 72.06%.@*CONCLUSION@#RBP is an idea marker for renal tubular damage, and is useful to diagnose renal tubular damage and assess the extent of the damage.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Acetilglucosaminidase
/
Urina
/
Biomarcadores
/
Estudos de Casos e Controles
/
Microglobulina beta-2
/
Creatinina
/
Proteínas Celulares de Ligação ao Retinol
/
Nefropatias
/
Túbulos Renais
Tipo de estudo:
Estudo observacional
Limite:
Adolescente
/
Adulto
/
Idoso
/
Aged80
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Journal of Central South University(Medical Sciences)
Ano de publicação:
2011
Tipo de documento:
Artigo
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