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Expression of TMPRSS3 in the rat cochlea following kanamycin ototoxicity / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences) ; (12): 987-991, 2011.
Artigo em Chinês | WPRIM | ID: wpr-814482
ABSTRACT
OBJECTIVE@#To establish the kanamycin-induced deafness model in SD rats, and to investigate the expression and significance of transmembrane protease, serine 3 (TMPRSS3) in the cochlea following kanamycin ototoxicity.@*METHODS@#A total of 40 male SD rats were randomly divided into 4 groups. The experimental rats received intramuscular kanamycin sulfate for 3, 7, and 14 consecutive days, and the control group were treated with normal saline for 14 days. Auditory brainstem responses (ABR) were obtained before and after the kanamycin administration. The expression of TMPRSS3 in the cochlea was identified and detected by immunohistochemistry and Western blot.@*RESULTS@#Kanamycin-induced deafness model in the SD rats was successfully established. ABR thresholds were increased and the expression of TMPRSS3 in the cochlea was reduced after the kanamycin injection (P<0.01).@*CONCLUSION@#TMPRSS3 may play an important role in normal cochlea function and involve in the process of aminoglycoside antibiotics induced deafness.
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Fisiologia / Serina Endopeptidases / Canamicina / Potenciais Evocados Auditivos do Tronco Encefálico / Ratos Sprague-Dawley / Cóclea / Surdez / Modelos Animais de Doenças / Toxicidade / Proteínas de Membrana Limite: Animais Idioma: Chinês Revista: Journal of Central South University(Medical Sciences) Ano de publicação: 2011 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Fisiologia / Serina Endopeptidases / Canamicina / Potenciais Evocados Auditivos do Tronco Encefálico / Ratos Sprague-Dawley / Cóclea / Surdez / Modelos Animais de Doenças / Toxicidade / Proteínas de Membrana Limite: Animais Idioma: Chinês Revista: Journal of Central South University(Medical Sciences) Ano de publicação: 2011 Tipo de documento: Artigo