Plasma copeptin levels in elderly victims of massive cerebral infarction and its relationship to early death / 中南大学学报(医学版)

ABSTRACT

OBJECTIVE@#To investigate copeptin levels in elderly patients who have suffered massive cerebral infarction, and to establish its correlation with early death.@*METHODS@#Forty-nine elderly patients with acute massive cerebral infarction and an age-matched control group of thirty normal people were established. Plasma copeptin levels of patient group were measured by ELISA at 24 h, 36 h, 5 d, and 14 d after onset of infarction. Glasgow-Pittsburgh coma scale (GPCS) were recorded within 24 h after onset, and both results were graded. Based on the 14-day mortality, the patient was divided into a death group and a survival group, and the correlations between graded copeptin level and GPCS to mortality were analyzed, as well as the consistency and accuracy of prognosis.@*RESULTS@#Plasma copeptin levels in the patient group were no differences between the 24 h, 36 h and 5 d point, and that of the 14 d was lower than that of the other points. Copeptin levels were significantly higher than in the control group at each test point (P25.0 pmol/L) showed better consistency and coincidence rate than GPCS score (< 20) in predicting early death.@*CONCLUSION@#Plasma copeptin level was increased in early phases of acute massive cerebral infarction in elderly patients; it may have predictive value for early death.