Prohibited substances in cosmetics: prospect of the toxicity of acrylamide / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 424-430, 2012.
Artigo
em Chinês
| WPRIM
| ID: wpr-814658
ABSTRACT
Prohibited substances in cosmetics refer to substances which must not be among the raw material ingredients of cosmetic products. These substances are absorbed mostly through skin, as well as via lung and gastrointestinal tract. Polyacrylamide is ubiquitously used in industry and its decomposition residue acrylamide (ACR) easily finds its way into cosmetic products. ACR can either be oxidized to epoxide glycidamide or conjugated with glutathione, hemoglobin or DNA; ultimately it is excreted in urine. ACR causes neurotoxicity, reproductive toxicity and tumors in rodents. Occupational exposure to ACR causes neurotoxicity in humans; however, epidemiological evidence have not unambiguously answered the question of whether ACR exposure can increase cancer risk for humans.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Resinas Acrílicas
/
Farmacocinética
/
Química
/
China
/
Cosméticos
/
Acrilamida
/
Toxicidade
/
Metabolismo
Limite:
Humanos
País/Região como assunto:
Ásia
Idioma:
Chinês
Revista:
Journal of Central South University(Medical Sciences)
Ano de publicação:
2012
Tipo de documento:
Artigo
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