Peginterferon alpha versus other antiviral regimes for Chinese HBeAg-positive chronic hepatitis B patients / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 1193-1207, 2013.
Artigo
em Inglês
| WPRIM
| ID: wpr-814839
ABSTRACT
OBJECTIVE@#To conduct a meta-analysis to determine the efficacy of peginterferon alpha (PEG-IFN α) therapy versus IFN α, adefovir dipivoxil (ADV) and entecavir (ETV) for HBeAg-positive chronic hepatitis B patients in China.@*METHODS@#MEDLINE database and 3 main Chinese biomedical databases between 1966 and 2012 was retrieved. Two reviewers independently screened all reports to identify randomized controlled trials that evaluated PEG-IFN α therapy for the treatment of chronic hepatitis B in China.@*RESULTS@#Fourteen trials met the eligibility criteria for this Meta analysis. PEG-IFN α therapy was more effective than IFN α therapy in achieving ALT normalization, serum HBV DNA clearance, HBeAg seroconversion, serum HBeAg clearance and fibrosis improvement in Chinese hepatitis B patients (P<0.05). PEG-IFN α was obviously superior to ETV in HBeAg seroconversion and serum HBeAg clearance (P<0.05), but the seroconversion rate was low. The combination therapy of PEG-IFN α and ADV was more effective than ADV monotherapy in ALT normalization, serum HBV DNA clearance and HBeAg seroconversion (P<0.05). PEG-IFN α showed no priority to other treatment regimes in HBsAg clearance.@*CONCLUSION@#Treatment with PEG-IFN α is safe and effective, and can be prescribed as firstline treatment options for chronic hepatitis B patients in China. Data are too limited to exclude a substantial benefit or harm of PEG-IFN α combination therapy for CHB patients in China.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Antivirais
/
Polietilenoglicóis
/
Adenina
/
China
/
Interferon-alfa
/
Hepatite B Crônica
/
Usos Terapêuticos
/
Tratamento Farmacológico
/
Quimioterapia Combinada
/
Organofosfonatos
Tipo de estudo:
Ensaio Clínico Controlado
/
Estudo prognóstico
/
Revisões Sistemáticas Avaliadas
Limite:
Humanos
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Journal of Central South University(Medical Sciences)
Ano de publicação:
2013
Tipo de documento:
Artigo
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