Expression of thioredoxin-2 for monitoring minimal residual disease in acute leukemia / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 383-387, 2013.
Artigo
em Chinês
| WPRIM
| ID: wpr-814870
ABSTRACT
OBJECTIVE@#To investigate the significance of human thioredoxin-2 (TRX-2) in monitoring minimal residual disease (MRD) in acute leukemia (AL).@*METHODS@#We used real-time quantitative PCR to serially quantitize TRX-2 expression levels in the bone marrow of AL patients at diagnosis (n=68), at complete hematologic remission (CHR, n=57) and at relapse (n=25). Another 25 normal donors served as normal controls. The upper limit of the bone marrow at 91 was regarded as the reference. TRX-2 expression level at CHR with 91). TRX-2 level was correlated to the expression level of MRD.@*CONCLUSION@#TRX-2 may be the marker for AL and used in MRD monitoring.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Tiorredoxinas
/
Leucemia Mieloide Aguda
/
Estudos de Casos e Controles
/
Neoplasia Residual
/
Diagnóstico
/
Leucemia-Linfoma Linfoblástico de Células Precursoras
/
Reação em Cadeia da Polimerase em Tempo Real
/
Genética
/
Metabolismo
Tipo de estudo:
Estudo diagnóstico
/
Estudo observacional
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Journal of Central South University(Medical Sciences)
Ano de publicação:
2013
Tipo de documento:
Artigo
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