Effect of stellate ganglion block on reconstruction of the left ventricle in spontaneously hypertensive rats / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 43-47, 2013.
Artigo
em Chinês
| WPRIM
| ID: wpr-814925
ABSTRACT
OBJECTIVE@#To determine the effect of stellate ganglion block on reconstruction of the left ventricle in spontaneously hypertensive rats (SHRs).@*METHODS@#Thirty-two 10-week-old male SHRs were randomly assigned into 4 groups a left stellate ganglion block group (group LS), a right stellate ganglion block group (group RS), a captopril group (group D) and a control group (group C). The arterial systolic blood pressure (SBP) was measured by ALC-NIBP measuring system. After 10 weeks, we observed the left ventricular mass index (LVMI), myocardial pathologic changes, and detected the endothelin (ET-1) and endothelial nitric oxide synthase (eNOS) level in the left ventricle by radioimmunoassay and the collagen protein level in the left ventricle by immunohistochemical method.@*RESULTS@#Compared with group LS and group C, the LVMI in group RS was lowered most notably (P<0.05) and pathological changes were improved obviously. The expression of eNOS in group RS was significantly increased and ET-1 significantly decreased (P<0.05) compared with that in group C and group LS. The expression of type I collagen fibers in group RS was significantly lower and type III collagen fibers significantly higher (P<0.05) when compared with that in group C and LS.@*CONCLUSION@#Right stellate ganglion block can not only decrease the arterial pressure but also reverse the reconstruction of the left ventricle.
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DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fisiologia
/
Ratos Endogâmicos SHR
/
Bloqueio Nervoso Autônomo
/
Gânglio Estrelado
/
Terapêutica
/
Remodelação Ventricular
/
Hipertensão
Limite:
Animais
Idioma:
Chinês
Revista:
Journal of Central South University(Medical Sciences)
Ano de publicação:
2013
Tipo de documento:
Artigo
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