Programmed necrosis: a new target for
ischemia reperfusion injury / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
; (12): 765-770, 2016.
Article
em Zh
| WPRIM
| ID: wpr-814966
Biblioteca responsável:
WPRO
ABSTRACT
Recent years, the researchers have found a new type of cell death, referred to programmed necrosis or necroptosis, which involves the death receptor and the ligand binds and is initiated under the inhibition of apoptosis pathway. Programmed necrosis possesses the morphological features of typical necrosis accompanied by inflammation. The receptor interacting protein kinase 1/3(RIPK1/3) can be inhibited by the specific inhibitors, such as necrostatin-1. RIPK1/3 could regulate programmed necrosis and play a key role in the process. The significance of programmed necrosis in ischemia-reperfusion injury (IRI) has been attracted great attention at present. Simultaneously, a series of studies have found it also involves in the IRI of heart, kidney, brain and retina.
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Traumatismo por Reperfusão
/
Apoptose
/
Proteína Serina-Treonina Quinases de Interação com Receptores
/
Imidazóis
/
Indóis
/
Inflamação
/
Necrose
Limite:
Humans
Idioma:
Zh
Revista:
Journal of Central South University(Medical Sciences)
Ano de publicação:
2016
Tipo de documento:
Article