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Influence of preventive use of vasopressin tannate on diabetes insipidus and serum sodium at the early postoperation of craniopharyngioma / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences) ; (12): 1058-1063, 2016.
Artigo em Chinês | WPRIM | ID: wpr-815133
ABSTRACT
To explore the influence of preventive use of vasopressin tannate on diabetes insipidus and serum sodium at the early postoperation of craniopharyngioma.


Methods:

The data of 83 patients, who underwent unilateral sub-frontal approach resection of craniopharyngioma between 2010 and 2014 by the same senior neurosurgeon, were retrospectively analyzed. The patients were divided into a vasopressin tannate group (used group) and a control group. The diabetes insipidus and serum sodium changes were compared between the two groups.


Results:

Compared with the control group, the incidence of diabetes insipidus decreased at the early postoperation in the vasopressin tannate group (P<0.05). There was high incidence of diabetes insipidus in patients with pituitary stalk excision and tumor close adhesion to the third ventricle floor at the early postoperation (P<0.05). Under such conditions, the incidence of diabetes insipidus in the vasopressin tannate group was decreased compared with the control group (P<0.05). Postoperative hypernatremia occurred in 37 patients (44.6%), and hyponatremia occurred in 60 patients (72.3%), the average time of the occurrence of hpernatremia and hyponatremia was 1.4 and 3.7 days after surgery. Postoperative high serum sodium and low serum sodium appeared alternately in 19 patients (22.9%). There was significant difference in the serum sodium distribution in the first day after surgery in both groups (P<0.05), and the percent of hpernatremia in the vasopressin tannate group was significantly less than that in the control group (P<0.05).


Conclusion:

Preventive use of vasopressin tannate can effectively reduce diabetes insipidus and hypernatremia incidence at the early postoperative stage after microsurgery for craniopharyngioma.
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Hipófise / Neoplasias Hipofisárias / Complicações Pós-Operatórias / Período Pós-Operatório / Cirurgia Geral / Arginina Vasopressina / Epidemiologia / Incidência / Estudos Retrospectivos / Craniofaringioma Tipo de estudo: Estudo de incidência / Estudo observacional / Estudo prognóstico Limite: Feminino / Humanos / Masculino Idioma: Chinês Revista: Journal of Central South University(Medical Sciences) Ano de publicação: 2016 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Hipófise / Neoplasias Hipofisárias / Complicações Pós-Operatórias / Período Pós-Operatório / Cirurgia Geral / Arginina Vasopressina / Epidemiologia / Incidência / Estudos Retrospectivos / Craniofaringioma Tipo de estudo: Estudo de incidência / Estudo observacional / Estudo prognóstico Limite: Feminino / Humanos / Masculino Idioma: Chinês Revista: Journal of Central South University(Medical Sciences) Ano de publicação: 2016 Tipo de documento: Artigo