Interactions between MAP4K1 and adaptor proteins / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 326-335, 2015.
Artigo
em Chinês
| WPRIM
| ID: wpr-815175
ABSTRACT
Mitogen-activated protein kinase kinase kinase kinase 1 (MAP4K1, also called hematopoietic progenitor kinase 1, HPK1) is a serine/threonine kinase. As a member of the MAP4K family, MAP4K1 is closely associated with various adaptor proteins such as caspase recruitment domain family member 11 (CARD11), hematopoietic cell-specific protein 1 (HS1), HPK1-interacting protein of 55 kD (HIP-55), growth factor receptor-bound protein 2 (GRB2) family, the linker for activated T-cells (LAT), SH2 domain containing leukocyte protein of 76 kD (SLP-76) family, homologues of the v-crk oncogene product (CRK) family, the B-cell adaptor molecule of 32 kD (BAM32), etc. It plays important roles in many immunoreactions, such as regulation of cellular proliferation and apoptosis, inhibition of TCR/BCR signaling and T/B/dendritic cells-mediated immune responses. Thus, MAP4K1 is involved in autoimmune diseases and plays a key role in tumor and inflammatory reaction.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Doenças Autoimunes
/
Transdução de Sinais
/
Proteínas Serina-Treonina Quinases
/
Proteínas Adaptadoras de Transdução de Sinal
/
Inflamação
/
Metabolismo
/
Neoplasias
Limite:
Humanos
Idioma:
Chinês
Revista:
Journal of Central South University(Medical Sciences)
Ano de publicação:
2015
Tipo de documento:
Artigo
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