Expression of RASAL2 in hepatocellular carcinoma and the clinical significance / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 250-255, 2015.
Artigo
em Chinês
| WPRIM
| ID: wpr-815181
ABSTRACT
OBJECTIVE@#To detect the expression of RA SAL2 in patients with hepatocellular carcinoma (HCC), and to investigate the association of RASAL2 expression with pathological characteristics and prognosis.@*METHODS@#Immunohistochemical SP method was used to detect the expression of RA SAL2 in 164 samples of HCC tissue and the adjacent tissue. Th e association of RA SAL2 expression with clinical features and prognosis was analyzed.@*RESULTS@#The expression of RASAL2 in adjacent tissue was significantly increased compared to that in HCC tissue (P0.05). The 5 years recurrence-free survival (RFS) in patients with low expression of RASLA2 was significantly reduced compared with that in patients with high expression of RASLA2 (P<0.001). Cox analysis showed that low expression of RASLA2 was the independent factor for recurrence and death in HCC patients after surgery (P<0.001).@*CONCLUSION@#Low expression of RRASAL2 is significantly associated with the poor prognosis of HCC, which is an independent factor for HCC prognosis.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Prognóstico
/
Proteínas de Transporte
/
Carcinoma Hepatocelular
/
Genética
/
Neoplasias Hepáticas
/
Metabolismo
/
Recidiva Local de Neoplasia
Tipo de estudo:
Estudo prognóstico
Limite:
Humanos
Idioma:
Chinês
Revista:
Journal of Central South University(Medical Sciences)
Ano de publicação:
2015
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS