Association of D2 dopamine receptor gene -141C Ins/Del polymorphisms with heroin dependence in Chinese Han population: a meta-analysis / 中南大学学报(医学版)

ABSTRACT

OBJECTIVE@#To evaluate the association between D2 dopamine receptor gene -141C Ins/Del polymorphism and heroin dependence in Chinese Han population.@*METHODS@#Chinese and foreign databases were searched for relevant articles published from the establishment of database to March 2014. Case-control studies on D2 dopamine receptor gene -141C Ins/Del polymorphism with heroin dependence in Chinese Han population were gathered with Meta-analysis by Stata 12.0 software after data abstraction.@*RESULTS@#Seven case-control studies on association between D2 dopamine receptor gene -141C Ins/ Del polymorphism and heroin dependence were included, which covered 3 211 heroin dependence patients and 1 979 controls. Meta-analysis results showed that the pooled odds ratio (OR), the 95% confidence interval (CI) and P value after combining genotypes were as follows Ins/Ins vs Del/Del OR=0.51, 95% CI 0.27-0.96, P=0.017; Ins/Ins vs Ins/Del+Del/Del OR=0.82, 95% CI 0.72-0.94, P=0.448; Ins/Ins+ Ins/Del vs Del/Del OR=0.53, 95% CI 0.28-0.98, P=0.019; Ins/Del vs Del/Del OR=0.59, 95% CI 0.32-1.07, P=0.045; Ins vs Del OR=0.79, 95% CI 0.71-0.89, P=0.101).@*CONCLUSION@#D2 dopamine receptor gene -141C Ins/Del polymorphism is associated with heroin dependence in Chinese Han population, and Chinese Han population with Ins allele gene deletion are at lower risk of heroin dependence.