Immune pathogenesis of IgA nephropathy and its drugable targets / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 96-101, 2014.
Artigo
em Chinês
| WPRIM
| ID: wpr-815455
ABSTRACT
IgA nephropathy (IgAN) is recognized as the most common immune complex related to the cause of glomerulonephritis worldwide. The disease is characterized by the predominant deposition of underglycosylated IgA1 in the mesangial area of glomeruli. Dysregulation of the immune system plays an important role in the pathogenesis of IgAN. Abnormalities restricted to T lymphocytes and/or B lymphocytes activation could be a critical causative factor in the over-production of underglycosylated IgA1.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Imunoglobulina A
/
Linfócitos B
/
Linfócitos T
/
Química
/
Mesângio Glomerular
/
Glomerulonefrite por IGA
/
Complexo Antígeno-Anticorpo
Tipo de estudo:
Estudo de etiologia
Limite:
Humanos
Idioma:
Chinês
Revista:
Journal of Central South University(Medical Sciences)
Ano de publicação:
2014
Tipo de documento:
Artigo
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