Morphologic studies of the retina in a new diabetic model; SHR/N:Mcc-cp rat
Yonsei Medical Journal
;
: 453-462, 1998.
Artigo
em Inglês
| WPRIM
| ID: wpr-81584
ABSTRACT
The pathogenesis of diabetic retinopathy has not been fully explained. The earliest histological lesion is the loss of intramural pericytes and thickening of the basement membrane. Increased activity of the polyol pathway is a probable mechanism for these two abnormalities. Investigations have suffered from the lack of an exact animal model simulating the human condition. Examination of the retina in the spontaneously diabetic SHR/NMcc-cp rat demonstrated degeneration and loss of intramural pericytes, a progressive increase in basement membrane thickness, and microinfarctions with an area of non-perfusion. Therefore, this model may be used to clarify the biochemical mechanisms linking the metabolic abnormalities of diabetes and retinopathy.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Ratos Endogâmicos SHR
/
Ratos Endogâmicos
/
Retina
/
Degeneração Retiniana
/
Retinopatia Diabética
/
Modelos Animais de Doenças
/
Animais
Limite:
Animais
Idioma:
Inglês
Revista:
Yonsei Medical Journal
Ano de publicação:
1998
Tipo de documento:
Artigo
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