Relation between ICOS signaling and Th9 cell polarization in mice infected with Schistosoma japonicum / 中国血吸虫病防治杂志
Chinese Journal of Schistosomiasis Control
;
(6): 436-439, 2018.
Artigo
em Chinês
| WPRIM
| ID: wpr-815919
ABSTRACT
To detect the expression level of ICOS on Th9 cells in mice infected with Schistosoma japonicum, and investigate the relation between ICOS signaling and Th9 cell polarization.Twenty-five mice with S. japonicum infection were used as models. IL-9+cells in CD4+ T cells and ICOS+ cells in Th9 cells of the mice were detected by flow cytometry 0, 4, 7, 9 weeks and 12 weeks after the infection.Compared with that 0 week after the infection, the proportion of Th9 cells in CD4+ T cells of the mice significantly increased 4, 7, 9, 12 weeks after the infection (all P < 0.05), and the proportion of ICOS+ cells in Th9 cells also markedly improved (P < 0.05).In S. japonicum infection, the ICOS signaling may have a regulatory effect on Th9 cell polarization.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Journal of Schistosomiasis Control
Ano de publicação:
2018
Tipo de documento:
Artigo
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