The Role of VEGF and Bruch's Membrane in the Development Choroidal Neovascularization
Journal of the Korean Ophthalmological Society
;
: 1473-1478, 2000.
Artigo
em Coreano
| WPRIM
| ID: wpr-81620
ABSTRACT
A major cause of blindness in elderly people is choroidal neovascularizapathogenesis and stimulating factor of CNV is not clearly understood. Vascular endothelial growth factor(VEGF)is a major stimulating factor for retinal neovascularization in ischemic retinopathy such as diabetic retinopathy, retinopathy of prematurity. But it is not known if VEGF is a stimulating factor for CNV. In this study, we have treated VEGF transgenic mice and C57BL/6 mice with laser. Different laser parameter for damage to retina pigment epithelium(RPE)only and for break of Bruch's membrane were used each. We were not able to induce CNV with only RPE damage. CNV wes induced when the break of Bruch's membrane was made and there was profuse CNV in VEGF transgenic mice rather than C57BL/6. These data suggest that the damage of Bruch's membrane may be the prerequisition for CNV formation and VEGF is the important stimulating factor for CNV.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Retina
/
Retinopatia da Prematuridade
/
Camundongos Transgênicos
/
Neovascularização Retiniana
/
Cegueira
/
Corioide
/
Lâmina Basilar da Corioide
/
Neovascularização de Coroide
/
Fator A de Crescimento do Endotélio Vascular
/
Retinopatia Diabética
Limite:
Animais
/
Humanos
Idioma:
Coreano
Revista:
Journal of the Korean Ophthalmological Society
Ano de publicação:
2000
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS