Basic principles, controversy and consensus on the use of antibiotics in the treatment of abdominal infection / 中国实用外科杂志

ABSTRACT

Complicated intra-abdominal infections(cIAIs)remain a majorchallenge in clinical practice.In addition to significant morbidity and mortality for patients,they consume substantial hospitalresources.It is compounded by the aging of thepopulation and the burden of chronic disease in these patients,as well as the increased prevalence of resistantbacteria in both the healthcare setting and the community.Besides timely effective source control and fluid resuscitation,rational use of antimicrobials isanintegral part of good clinical practice.Once cIAIs are suspected or diagnosed,anti-infective treatment should be given as soon as possible.At this time,empirical antiinfective treatment is particularly important due to the lack of microbial culture and drug susceptibility results.In the process of anti-infective treatment,the application of anti-infective drugs can be adjusted according to the culture of pathogens and the results of drug sensitivity experiments.