Recent Improvements in Genomic and Transcriptomic Understanding of Anaplastic and Poorly Differentiated Thyroid Cancers
Endocrinology and Metabolism
;
: 44-54, 2020.
Artigo
em Inglês
| WPRIM
| ID: wpr-816630
ABSTRACT
Anaplastic thyroid cancer (ATC) is a lethal human cancer with a 5-year survival rate of less than 10%. Recently, its genomic and transcriptomic characteristics have been extensively elucidated over 5 years owing to advance in high throughput sequencing. These efforts have extended molecular understandings into the progression mechanisms and therapeutic vulnerabilities of aggressive thyroid cancers. In this review, we provide an overview of genomic and transcriptomic alterations in ATC and poorly-differentiated thyroid cancer, which are distinguished from differentiated thyroid cancers. Clinically relevant genomic alterations and deregulated signaling pathways will be able to shed light on more effective prevention and stratified therapeutic interventions for affected patients.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Glândula Tireoide
/
Neoplasias da Glândula Tireoide
/
Taxa de Sobrevida
/
Genoma
/
Sequenciamento de Nucleotídeos em Larga Escala
/
Transcriptoma
/
Carcinoma Anaplásico da Tireoide
Limite:
Humanos
Idioma:
Inglês
Revista:
Endocrinology and Metabolism
Ano de publicação:
2020
Tipo de documento:
Artigo
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