Study on Molecular Mechanism of Xiaochaihu Decoction for Sepsis Based on TCMIP Platform / 中国药房
China Pharmacy
;
(12): 1506-1512, 2019.
Artigo
em Chinês
| WPRIM
| ID: wpr-816915
ABSTRACT
OBJECTIVE: To investigate the substance basis and mechanism of Xiaochaihu decoction in treatment of sepsis, and to provide reference for clinical application and R&D of the decoction. METHODS: Based on TCM integrative pharmacology platform (TCMIP), chemical component analysis of Xiaochaihu decoction, disease target prediction, gene function and pathway enrichment analysis were all performed. The multi-dimensional network relationship of “TCM-chemical components-core targets-key pathways” was established, and the mechanism of Xiaochaihu decoction in treatment of sepsis was investigated. RESULTS: A total of 224 predicted chemical ingredients of Xiaochaihu decoction (including saikoside, ginsenoside, glycyrrhizin, etc.) interacted with 118 key targets about sepsis, including PF4, MYD88, TLR4, CD14, NOS3, etc. Its anti-sepsis mechanism involved nervous system, endocrine system, immune response and energy metabolism, etc. CONCLUSIONS: Based on “neuronal- endocrine-immune-metabolism”, Xiaochaihu decoction achieved its role in regulating sepsis by multi-level, multi-channel and multi-channel. This research may reveal the potential mechanism of Xiaochaihu decoction for sepsis, and the prescription provide theoretical basis for further experimental research of pharmacodynamic substance basis and mechanism of action.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
China Pharmacy
Ano de publicação:
2019
Tipo de documento:
Artigo
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