Therapeutic Efficacy of Reteplase versus Alteplase in the Treatment of Acute Myocardial Infarction in China :A Meta-analysis / 中国药房
China Pharmacy
;
(12): 1279-1284, 2019.
Artigo
em Chinês
| WPRIM
| ID: wpr-816978
ABSTRACT
OBJECTIVE: To evaluate therapeutic efficacy of reteplase versus alteplase in the treatment of acute myocardial infarction in China, and to provide evidence-based reference for clinical treatment. METHODS: Retrieved from Cochrane library, PubMed, Embase, Medline, CJFD, CSJD, Wanfang database by computor, etc., also by manual search, RCTs about therapeutic efficacy (recanalization rate of thrombolysis) of reteplase (trial group) versus alteplase (control group) in the treatment of acute myocardial infarction in China were collected from Jan. 1995 to Sept. 2018. After data extraction and quality evaluation with Cochrane system evaluator manual 5.1.0, Meta-analysis was performed for recanalization rate of thrombolysis by using Rev Man 5.3 software. RESULTS: A total of 23 RCTs were included, involving 1 742 patients. Results of Meta-analysis showed that recanalization rate of thrombolysis in trial group was significantly higher than control group, with statistical significance [OR=0.61,95%CI(0.50,0.73),P<0.001]. Sub-group Meta-analysis was performed according to the successful time of thrombolysis. Results of Meta-analysis showed that recanalization rate of thrombolysis in trial group 1 h [OR=0.38,95%CI(0.25,0.58),P<0.001], 1.5 h [OR=0.44,95%CI(0.25,0.79),P=0.006] and 2 h [OR=0.62,95%CI(0.42,0.92),P=0.02] after thrombolysis were significantly higher than control group, with statistical significance. CONCLUSIONS: The recanalization rate of thrombolysis by reteplase in Chinese patients with acute myocardial infarction in better than by alteplase.
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Índice:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Guia de Prática Clínica
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Revisões Sistemáticas Avaliadas
Idioma:
Chinês
Revista:
China Pharmacy
Ano de publicação:
2019
Tipo de documento:
Artigo
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