Meta-analysis of Risk Factors of Linezolid-induced Thrombocytopenia / 中国药房
China Pharmacy
;
(12): 980-984, 2019.
Artigo
em Chinês
| WPRIM
| ID: wpr-817026
ABSTRACT
OBJECTIVE: To evaluate risk factors of linezolid-induced thrombocytopenia systematically, and to provide reference for rational drug use in clinic. METHODS: Retrieved from PubMed, Embase, Cochrane library, Web of Science, CBM, CNKI and Wanfang database, during database establishment to Oct. 2018, clinical studies about risk factors of linezolid-induced thrombocytopenia were collected, and the data of literatures met criteria were collected. After Newcastle-Ottawa scale (NOS) was applied for evaluating the quality of included literatures. Meta-analysis was conducted by using Rev Man 5.3 software. RESULTS: Sixteen clinical studies involving 2 264 patients in total were included. Results of Meta-analysis showed that daily per kg dose (DKPD) [SMD=0.62, 95%CI(0.29,0.95), P=0.000 2], low platelet count before medication [SMD=-0.90, 95%CI(-1.62, -0.18), P=0.01], low creatinine clearance rate [SMD=-0.65, 95%CI(-1.10,-0.19), P=0.005], long treatment course [SMD=0.45, 95%CI(0.18,0.71), P=0.000 9], low body weight [SMD=-0.36, 95%CI(-0.60,-0.11),P=0.005] significantly influenced the occurrence of thrombocytopenia. CONCLUSIONS: The risk factors associated with linezolid-induced thrombocytopenia include low baseline platelet count, low creatinine clearance rate, low body weight, long medication course and high DKPD.
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Índice:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Estudo de etiologia
/
Fatores de risco
/
Revisões Sistemáticas Avaliadas
Idioma:
Chinês
Revista:
China Pharmacy
Ano de publicação:
2019
Tipo de documento:
Artigo
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