Optimization of Water Extraction Technology of Chaihu Anxin Capsules by Box-Behnken Response Surface Method Combined with Multi-index Comprehensive Scoring Method / 中国药房
China Pharmacy
;
(12): 632-637, 2019.
Artigo
em Chinês
| WPRIM
| ID: wpr-817064
ABSTRACT
OBJECTIVE: To optimize the water extraction technology of Chaihu anxin capsules. METHODS: Taking comprehensive scoring value of the contents of gallic acid,chlorogenic acid,puerarin,glycoside,rutin,cinnamic acid, quercetin and the yield of extract as investigation index, using multiple of adding liquid, soaking time, reflux time and extraction times as factors, water extraction technology of Chaihu anxin capsule was optimized by Box-Behnken response surface method based on single factor test. Validation test was conducted. RESULTS: The optimal extraction technology of Chaihu anxin capsules was adding 11 times of water, soaking for 10 h, extracting for 2 times, refluxing for 1.5 h each time. In validation test, the relative deviation of comprehensive scoring value to predicted value was 1.87% for 3 batches of samples (RSD<2%, n=3). CONCLUSIONS: The optimal extraction technology is simple, stable and suitable for further production of Chaihu anxin capsules.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Estudo prognóstico
Idioma:
Chinês
Revista:
China Pharmacy
Ano de publicação:
2019
Tipo de documento:
Artigo
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