Successful Treatment of Fungemia Caused by Cyberlindnera fabianii with Anidulafungin: A Case Report / 대한임상미생물학회지
Annals of Clinical Microbiology
;
: 94-97, 2015.
Artigo
em Inglês
| WPRIM
| ID: wpr-81745
ABSTRACT
Cyberlindnera fabianii (previously known as Hansenula fabianii, Pichia fabianii, and Lindnera fabianii) is a yeast species that forms a biofilm, allowing it to resist azole drugs. In this study, we report a case of fungemia with C. fabianii that was successfully treated with anidulafungin. In this case, the organism was initially misidentified as Candida utilis (with a high probability of 93%, suggesting good identification) using the VITEK 2 yeast identification card (YST ID; bio-Merieux, USA). The species responsible for the patient's fungemia was correctly identified after sequencing the internally transcribed spacer region and the D1/D2 domain of the large subunit (26S) rDNA gene. The CLSI M27-A3 broth microdilution method was used to determine the in vitro antifungal activity of anidulafungin and fluconazole against C. fabianii. The MICs of anidulafungin and fluconazole were found to be 0.03 microg/mL and 2 microg/mL, respectively. The patient recovered after 14 days of anidulafungin treatment.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Pichia
/
Leveduras
/
Candida
/
DNA Ribossômico
/
Fluconazol
/
Fungemia
/
Biofilmes
/
Danazol
Limite:
Humanos
Idioma:
Inglês
Revista:
Annals of Clinical Microbiology
Ano de publicação:
2015
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS