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Relationship between Total Serum IgE Level and Allergic Sensitization/Bronchial Hyperresponsiveness in Preschool Children with Asthma / 소아알레르기및호흡기학회지
Pediatric Allergy and Respiratory Disease ; : 260-270, 2009.
Artigo em Coreano | WPRIM | ID: wpr-81764
ABSTRACT

PURPOSE:

This study aimed to evaluate the relationship between the serum IgE level and allergic sensitization/bronchial hyperresponsiveness (BHR) in preschool children with asthma.

METHODS:

One hundred nine asthmatic children age 4-6 years were enrolled. Total serum IgE levels, and specific IgE level to food and inhalant allergens were tested using Pharmacia Auto CAP system RAST(R)FEIA, methacholine bronchial challenge test (PCw=Provocative concentration at wheezing. PCsat=Provocative concentration at 5% fall of oxygen saturation) were performed in all subjects. They were divided into 3 groups according to the serum IgE levelless than 120 IU/mL (group A, n=38), 120 to 1,000 IU/mL (group B, n=45), and greater than 1,000 IU/mL (group C, n=26). The relationships with allergic sensitization and BHR were evaluatied among the 3 groups.

RESULTS:

Sensitization to foods and inhalant allergens were related to a higher total serum IgE levels. However, BHR and severity of asthma were not related to higher total serum IgE levels, except in group B. Presence of atopic dermatitis, high serum eosinophil (>450/mm3), allergic sensitization to foods and inhalants were related to high serum IgE greater than 1,000 IU/mL. (odds ratio ; 95% confidence interval=4.4;1.7-11.2, 3.2;1.2-9.2, 4.8;1.7-13.2, 5.5;1.2-24.9)

CONCLUSION:

Moderately elevated total serum IgE was related to allergic sensitization, severity of asthma and BHR. However highly elevated total serum IgE was related to only allergic sensitization. This may be attributed to other factors in preschool children with asthma.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Oxigênio / Asma / Testes de Provocação Brônquica / Imunoglobulina E / Alérgenos / Sons Respiratórios / Cloreto de Metacolina / Hiper-Reatividade Brônquica / Dermatite Atópica / Eosinófilos Limite: Criança / Criança, pré-escolar / Humanos Idioma: Coreano Revista: Pediatric Allergy and Respiratory Disease Ano de publicação: 2009 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Oxigênio / Asma / Testes de Provocação Brônquica / Imunoglobulina E / Alérgenos / Sons Respiratórios / Cloreto de Metacolina / Hiper-Reatividade Brônquica / Dermatite Atópica / Eosinófilos Limite: Criança / Criança, pré-escolar / Humanos Idioma: Coreano Revista: Pediatric Allergy and Respiratory Disease Ano de publicação: 2009 Tipo de documento: Artigo