Stem cell-related techniques for the treatment of liver failure: A basic and clinical translational study / 医学研究生学报

ABSTRACT

Acute liver failure (ALF) is a severe clinical syndrome with rapid progression, poor prognosis and high mortality. Liver transplantation is the most effective option for the treatment of ALF, but only a few ALF patients can receive the donor liver in time due to the insufficient supply of the organ. Stem cell-related techniques, including stem cell transplantation, bioartificial liver, etc., with their roles of detoxication, synthesis, metastasis and secretion, have brought some hope for the solution of this problem. This article presents an overview of the three aspects as follows mechanisms and clinical translation of stem cell transplantation for ALF, establishment of the coculture system for mesenchymal stem cells with porcine hepatocytes and clinical translation of the coculture-based bioartificial liver, and establishment of human-induced hepatocytes and clinical translation of bioartificial liver based on human-induced seed cells.