Efficacy of chemotherapy combined with IMRT in the treatment of patients with locally advanced non-small cell lung cancer / 医学研究生学报

ABSTRACT

Objective At present, there are few studies on the application of intensity-modulated radiation therapy (IMRT) combined with chemotherapy in the treatment of non-small cell carcinoma (NSCLC). The article aimed to analyze the efficacy of chemotherapy combined with IMRT on patients with locally advanced NSCLC and the impact on life quality.Methods From January 2012 to December 2014, 160 patients with locally advanced NSCLC were treated in our department of radiotherapy. The patients were divided into IMRT group(chemotherapy of paclitaxel or gemcitabine combined with cisplatin, IMRT) and control group(chemotherapy of paclitaxel or gemcitabine combined with cisplatin) according to different treatments, 80 patients in each group. The patients′ treatment efficacy along with its impact on the patients′ life quality were compared between two groups.Results The effective rate of IMRT group was higher than that of control group(78.75% vs 47.50%, P0.05). Conclusion Chemotherapy combined with IMRT can significantly improve the therapeutic effect in patients with locally advanced NSCLC, featuring less side effects, high safety, improved life quality and lengthened survival time. Therefore, the treatment is worthy of clinical application.