Mechanisms of deoxycholic acid to promote the initiation and progression of colorectal cancer / 医学研究生学报

ABSTRACT

Colorectal cancer is a malignant disease of digestive system, with increasing morbidity. As a risk factor of colorectal cancer, high fat diet changes the secretory form of hepatic bile acids and stimulates its secretion. As a result, it increases the concentration of bile acids in the large intestine. Deoxycholic acid promotes the initiation and progression of colorectal cancer through affecting various intracellular signals, modulating expression of multiple genes and influencing the balance of the gut microbiota. The article reviewes the mechanisms of deoxycholic acid to promote the initiation and progression of colorectal cancer.