Biological behavior of neutrophils in sepsis / 医学研究生学报

ABSTRACT

Neutrophils are a type of important native immune cells that play a very important role in nonspecific cellular immunity. As the first defensive army against microbial pathogens, especially pyogenic bacteria, neutrophils perform the functions of chemotaxis and phagocytosis, but meanwhile they may induce different degrees of inflammatory response and cause local or systemic immuno-pathologic impair. At present, the changes in the pathophysiological and biological behaviors of neutrophils in sepsis need to be studied more comprehensively, and effective regulation and utilization of neutrophils are required in the treatment of sepsis. This review summarizes some important pathophysiological changes in neutrophils in sepsis, including apoptosis, autophagy and pyroptosis, focusing on the biological behavior of neutrophils in the development and progression of sepsis.