Progress research of neutrophil extracellular traps in sepsis and intestinal barrier function / 医学研究生学报

ABSTRACT

Sepsis is one of the most important factors leading to death in critically ill patients. Neutrophils are the main effector cells that play an immune response during sepsis. In addition to exerting chemotaxis and phagocytosis, neutrophils are also capable of releasing neutrophil extracellular traps (NETs) composed of double-stranded DNA and antibacterial proteins embedded in DNA. The persistent over-formation of NETs in sepsis will cause thrombosis and multiple organ dysfunction (MOD). Gut as the initial organ of MOD, sepsis and intestinal barrier damage is an important cause of MOD. Studies have confirmed that NETs are closely related to intestinal barrier damage, and excessive formation of NETs in the intestine can cause persistent inflammation of the intestinal mucosa, leading to intestinal dysfunction. This article outlines the latest advances in NETs in sepsis and intestinal function, providing new directions for the early diagnosis and treatment of sepsis.