Effects of optimum analgesia and sedation on enhanced rehabilitation in critically ill patients / 医学研究生学报

ABSTRACT

Effective analgesia and sedation is important for critically ill patients. .It aims to eliminate or relieve pain, anxiety and agitation during intensive care and at the same time help to reduce the host stress response and inflammation, decrease oxygen exhaustion and demand, and protect organ function and enhances recovery. The principle of analgesia and sedation is to give priority to analgesia, minimize sedation, and patient-centered humanistic care to ensure the smooth progress of intensive treatment, and reduce stress response and medically related secondary damage. To achieve enhanced rehabilitation in critically ill patients, we proposed three aspects for optimum analgesia and sedation. Firstly, target-based analgesia and sedation protocol is imperative for achieving effective analgesia and sedation, and also it is important to avoid adverse effects caused by over use of drugs. Secondly, multi-modal analgesia is preferable to maximize the analgesia while being able to limit the dose and thereby side effects of opioids, such as inhibition of respiratory system and bowl movement. At last, prevention and management of acquired delirium is helpful for early initiation of physical exercise and improvement of short- and long-term cognition function.