Research progress of circRNA and its clinical significance in gastric cancer / 医学研究生学报

ABSTRACT

Circular RNA (circRNA) is a class of endogenous non-coding RNA molecules with a stable closed loop structure formed by reverse splicing. It is more conserved and stable than linear RNA and involves cell development, proliferation, differentiation and apoptosis. Long-term and large-scale studies show the dysregulation of circRNA is associated with the risk of invasion, staging, metastasis, and postoperative recurrence of gastric cancer. This paper reviews the structure, classification, function of circRNA and its clinical significance in gastric cancer.