Epigenetics-based regulation of uptake drug transporter expression is a new approach for cancer drug resistance intervention / 医学研究生学报

ABSTRACT

Drug resistance is a key factor for poor clinical efficacy of chemotherapy. One of the important reasons for drug resistance is the abnormal expression of drug metabolizing enzymes and drug transporters, which results in the decrease of drug concentration in cancer cells. In this paper, the mechanism of abnormal uptake transporter expression in tumors is analyzed from aspects of drug metabolism enzymes and transporters and tumor drug resistance, drug epigenetics and drug resistance, and potential targets of renal cancer drug resistance, such as OCT2. It is proposed that the regulation of uptake drug transporter expression in tumors by epigenetic mechanism is a new way to reverse drug resistance in tumors.