Advances in animal models of traumatic brain injury / 医学研究生学报

ABSTRACT

Traumatic brain injury (TBI) is a serious global public health and socio-economic problem with high disability and mortality. At present, the following TBI animal models are widely used in experimental　research - weight-drop injury models, fluid percussion injury models, controlled cortical injury models, penetrating ballistic-like brain injury models, and blast injury models. Although the TBI animal models replicate most of the histopathological and functional outcomes observed clinically, the existing animal models can not fully replicate human TBI. Researchers need to consider carefully when using experimental TBI models to ensure that the most appropriate models are selected to solve the research problems. In this paper, the principles and characteristics of these five models are briefly reviewed.