Advances in the study of brain function changes in inflammatory bowel disease / 医学研究生学报

ABSTRACT

Inflammatory bowel disease(IBD) is a chronic non-specific inflammatory disorder that commonly affects gastrointestinal tract. The cause is not clear. Previous studies have shown that IBD patients often suffer from anxiety and depression, which may be associated with impaired brain structure and function and changes in gut microbiome. Based on these findings, many researches indicate brain-gut-microbiome axis may play an important role in the occurrence and development of IBD. Blood oxygenation level dependent functional magnetic resonance (BOLD-fMRI) can detect brain function area with special response accurately and objectively, which helps to investigate the changes of brain function and its pathogenesis in IBD patients. This article reviews the current status and future prospects in IBD brain function changes based on the brain-gut-microbiome axis.