Research progress of long non-coding RNA in the invasion and metastasis of hepatocellular carcinoma / 医学研究生学报

ABSTRACT

Long non-coding RNA (LncRNA) refers to a class of RNA molecules that are not capable of encoding a protein that is greater than 200 nucleotides in length. It is suggested that LncRNA plays a promoting or inhibiting role in regulating tumor growth, invasion and metastasis through a variety of molecular mechanisms. Primary hepatocellular carcinoma (HCC) is the second leading cause of cancer death in China. Recurrence and metastasis of HCC after operation is the main cause of low survival rate. Therefore, systematically explore the mechanism of lncRNA that promotes or inhibits the invasion and metastasis of HCC, and contributes to the targeted therapy, prediction of recurrence and metastasis and prognosis of HCC. This article reviews the recent research on the mechanism of LncRNA and invasion and metastasis of HCC, in order to provide new ideas for the prevention and treatment of HCC.