Progress research of the contribution over the interaction between intestinal flora and host miRNA to diabetes mellitus / 医学研究生学报

ABSTRACT

Gut microbiota plays an important role in maintaining intestinal barrier function and keeping body health. Changes of its structure and function are related to many common human diseases. As a class of non-coding single-stranded molecules, numerous studies have shown that the regulatory effect of microRNAs (miRNAs) at the gene level, can affect almost all biological processes in the body. In addition, gut microbiota can interact with miRNAs, and play a regulatory role in maintaining intestinal homeostasis and preventing metabolic diseases(diabetes) together. In this paper, we review the regulation of gut microbiota-miRNAs interaction, and how to regulate the occurrence and development of diabetes mellitus through this interaction.