Case-control study of vitamin B12 and metabolite MMA and transporter TCN2 in children with ASD / 中国学校卫生
Chinese Journal of School Health
;
(12): 490-492, 2019.
Artigo
em Chinês
| WPRIM
| ID: wpr-818803
ABSTRACT
Objective@#To investigate the level of vitamin B12 in children with autism spectrum disorder(ASD), and provide a theoretical basis for early detection and drug treatment of ASD.@*Methods@#A total of 89 ASD cases and 89 matched controls were collected. The levels of urinary methylmalonic acid (MMA) and serum vitamin B12, Transcobalamin Ⅱ (TCN2) were determined by enzyme-linked immunosorbent assay (ELISA). TCN2 gene rs1801198 was genotyped by SNaPshot.@*Results@#The serum levels of vitamin B12 and TCN2 in children with ASD [(369.08±131.88)pmol/L, (1.56±0.16)ng/mL] were significantly lower than those in the control group[(485.16±200.33)pmol/L, (1.71±0.17)ng/mL](t=-5.47, -5.92, P<0.05). The level of MMA in urine of ASD children [(758.97±106.96) ng/mL] was significantly higher than that in the control group[(693.66±121.72)ng/mL](t=3.94, P<0.05); The genetic polymorphism of rs1801198 locus was not associated with the risk of ASD(P>0.05), and there was no significant correlation with serum TCN2 level(F=1.16, P>0.05).@*Conclusion@#ASD children are at a potential deficiency of vitamin B12 and should strengthen their nutritional interventions while conducting ASD interventions.
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Índice:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Estudo observacional
/
Fatores de risco
/
Estudo de rastreamento
Idioma:
Chinês
Revista:
Chinese Journal of School Health
Ano de publicação:
2019
Tipo de documento:
Artigo
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