Detection of the risk signals of drug-induced liver injury: Challenges and advances / 临床肝胆病杂志

ABSTRACT

Early detection and effective monitoring of the risk signals of drug-induced liver injury (DILI) are of great importance in the prevention and management of DILI in clinical practice. However, the lack of high sensitivity and strong specificity in the detection of risk signals brings great challenges to the identification and monitoring of risk signals and causes difficulties in establishing the strategies for the prevention and control of DILI. This article analyzes the challenges in the identification of DILI risk signals, summarizes the applicability and limitations of risk signals based on commonly used indices in early recognition, prediction, and early warning of DILI, proposes an identification and monitoring model for DILI risk signals based on specific biomarkers, and elaborates on their potential clinical values, so as to provide a scientific basis for developing targeted strategies for the prevention and control of the risk of DILI.