Association between mitochondria and hepatocellular injury / 临床肝胆病杂志

ABSTRACT

The mitochondria in liver tissue not only provides energy for substance metabolism in hepatocytes, but also participates in hepatocellular injury and even apoptosis. It also plays an important role in several pathological processes closely associated with hepatocellular injury and apoptosis, such as hepatitis, hepatic fibrosis, precancerous lesion, and liver cancer. This article elaborates on the association between mitochondria and hepatocellular injury from the following aspects the important role of the change in mitochondrial membrane permeability in hepatocellular injury, hepatocellular injury accelerated by ATP synthesis disorder and consumption, and the association of abnormal Ca2+ homeostasis in hepatocellular mitochondria with hepatocellular injury, in order to provide a theoretical basis for mitochondria-targeted prevention and treatment of chronic liver diseases due to hepatocellular injury.