Cytokine profile in murine toxoplasmosis
Asian Pacific Journal of Tropical Medicine
;
(12): 16-19, 2011.
Artigo
em Inglês
| WPRIM
| ID: wpr-819569
ABSTRACT
OBJECTIVE@#To investigate which cytokines are produced after acute infection of mice with Toxoplasma gondii (T. Gondii) RH strain.@*METHODS@#Mus domesticus domesticus mice in infected group were inoculated with with highly virulent T. Gondii RH strain by intraperitoneally. Serum samples were obtained from infected and non-infected mice for cytokine levels for ELISA assay.@*RESULTS@#The concentrations of tumor necrosis factor-α, interferon-γ, interleukin (IL)-10 and IL-12 in the cardiac blood sample of the infected mice were significantly higher than those in uninfected controls (P0.05).@*CONCLUSIONS@#According to our findings, immune response into T helper type 1 was predominant during acute T. gondii infection. Further characterization and purification of Toxoplasma molecule(s) implicated in the regulation of cytokines could lead to the development of new drug prospects to control Toxoplasma infection.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Toxoplasma
/
Sangue
/
Ensaio de Imunoadsorção Enzimática
/
Química
/
Toxoplasmose
/
Citocinas
/
Células Th1
/
Soro
/
Alergia e Imunologia
Limite:
Animais
Idioma:
Inglês
Revista:
Asian Pacific Journal of Tropical Medicine
Ano de publicação:
2011
Tipo de documento:
Artigo
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