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Safety of polyethylene glycol recombinant human granulocyte colony-stimulating factor in treating non-small cell lung cancer patients at I b stage
Article em En | WPRIM | ID: wpr-819756
Biblioteca responsável: WPRO
ABSTRACT
OBJECTIVE@#To investigate resistance and safety of HHPG-19K in treating non-small cell lung cancer patients.@*METHODS@#A total of 30 cases were selected and randomly divided into 5 groups: three HHPG-19K groups of different dosage (60 μg/kg/day, 100 μg/kg/day, 200 μg/kg/day), positive control group (Filgrastim, namely G-CSF5 μg/kg/day) and negative control group. Safety indexes of 5 groups were observed and compared.@*RESULTS@#All patients had adverse event (100%) in three HHPG-19K groups, and increased ALP, ALT and AST were main events. The degree was mild to moderate. There was no significant difference in the incidence of adverse event between dosage groups and positive control group no difference. But the incidence of negative control group was 13%, which was significantly lower than dosage groups and positive control group.@*CONCLUSIONS@#non-small cell lung cancer patients have satisfactory tolerance to HHPG-19K, and have no resistance. Besides, dosage at 100 μ g/kg is the most safe.
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Texto completo: 1 Índice: WPRIM Assunto principal: Patologia / Polietilenoglicóis / Proteínas Recombinantes / Esquema de Medicação / Protocolos de Quimioterapia Combinada Antineoplásica / Mortalidade / Fator Estimulador de Colônias de Granulócitos / Cisplatino / Resultado do Tratamento / Carcinoma Pulmonar de Células não Pequenas Tipo de estudo: Prognostic_studies Limite: Adult / Aged / Female / Humans / Male Idioma: En Revista: Asian Pacific Journal of Tropical Medicine Ano de publicação: 2013 Tipo de documento: Article
Texto completo: 1 Índice: WPRIM Assunto principal: Patologia / Polietilenoglicóis / Proteínas Recombinantes / Esquema de Medicação / Protocolos de Quimioterapia Combinada Antineoplásica / Mortalidade / Fator Estimulador de Colônias de Granulócitos / Cisplatino / Resultado do Tratamento / Carcinoma Pulmonar de Células não Pequenas Tipo de estudo: Prognostic_studies Limite: Adult / Aged / Female / Humans / Male Idioma: En Revista: Asian Pacific Journal of Tropical Medicine Ano de publicação: 2013 Tipo de documento: Article