Predicted essential proteins of Plasmodium falciparum for potential drug targets
Asian Pacific Journal of Tropical Medicine
; (12): 352-354, 2012.
Article
em En
| WPRIM
| ID: wpr-819769
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE@#To identify novel drug targets for treatment of Plasmodium falciparum.@*METHODS@#Local BLASTP were used to find the proteins non-homologous to human essential proteins as novel drug targets. Functional domains of novel drug targets were identified by InterPro and Pfam, 3D structures of potential drug targets were predicated by the SWISS-MODEL workspace. Ligands and ligand-binding sites of the proteins were searched by Ef-seek.@*RESULTS@#Three essential proteins were identified that might be considered as potential drug targets. AAN37254.1 belonged to 1-deoxy-D-xylulose 5-phosphate reductoisomerase, CAD50499.1 belonged to chorismate synthase, CAD51220.1 belonged to FAD binging 3 family, but the function of CAD51220.1 was unknown. The 3D structures, ligands and ligand-binding sites of AAN37254.1 and CAD50499.1 were successfully predicated.@*CONCLUSIONS@#Two of these potential drug targets are key enzymes in 2-C-methyl-d-erythritol 4-phosphate pathway and shikimate pathway, which are absent in humans, so these two essential proteins are good potential drug targets. The function and 3D structures of CAD50499.1 is still unknown, it still need further study.
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Plasmodium falciparum
/
Proteínas
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Química
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Malária Falciparum
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Homologia Estrutural de Proteína
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Usos Terapêuticos
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Tratamento Farmacológico
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Ligantes
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Conformação Molecular
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Antimaláricos
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Asian Pacific Journal of Tropical Medicine
Ano de publicação:
2012
Tipo de documento:
Article