Antioxidant and antiangiogenic activities of the essential oils of Myristica fragrans and Morinda citrifolia
Asian Pacific Journal of Tropical Medicine
;
(12): 294-298, 2012.
Artigo
em Inglês
| WPRIM
| ID: wpr-819782
ABSTRACT
OBJECTIVE@#Toinvestigate the anti-angiogenic activity and antioxidant properties of Myristica fragrans (M. fragrans) (nutmeg) and Morinda citrifolia (M. citrifolia)(mengkudu) oils.@*METHODS@#The nutmeg and megkudu essential oils were obtained by steam distillation. The antioxidant activities of both essential oils were determined by beta-carotene/linoleic acid bleaching assay and reducing power while the anti-angiogenic activity was investigated using rat aortic ring assay using various concentrations.@*RESULTS@#The results showed that nutmeg oil has higher antioxidant activity than mengkudu oil. The nutmeg oil effectively inhibited the oxidation of linoleic acid with (88.68±0.1)% while the inhibition percentage of oxidation of linoleic acid of the mengkudu oil is (69.44±0.4)%. The nutmeg oil and mengkudu oil showed reducing power with an EC(50) value of 181.4 μg/mL and 3 043.0 μg/mL, respectively. The antiangiogenic activity of nutmeg oil showed significant antiangiogenic activity with IC(50) of 77.64 μg/mL comparing to mengkudu oil which exhibits IC(50) of 109.30 μg/mL.@*CONCLUSIONS@#Bioactive compound(s) will be isolated from the nutmeg essential oil to be developed as antiangiogenic drugs.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Aorta
/
Farmacologia
/
Sementes
/
Óleos Voláteis
/
Análise de Variância
/
Ratos Sprague-Dawley
/
Inibidores da Angiogênese
/
Myristica
/
Morinda
/
Relação Dose-Resposta a Droga
Limite:
Animais
Idioma:
Inglês
Revista:
Asian Pacific Journal of Tropical Medicine
Ano de publicação:
2012
Tipo de documento:
Artigo
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